Drug interactions
Bortezomib + Palifermin
Severity: Moderate
Bortezomib and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy may stimulate proliferation of epithelial cells and increase the severity and duration of mucositis. Bortezomib is an antineoplastic agent, so the same timing caution applies. Palifermin has not been established for use with bortezomib.
What this interaction means in plain words
Bortezomib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin stimulates epithelial cell growth, which can sensitize proliferating mucosal cells to cytotoxic damage when given near chemotherapy.
What to do
Do not give palifermin within 24 hours before, during or within 24 hours after bortezomib. Monitor for oral mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Palifermin
Frequently asked questions
Can I take Bortezomib with Palifermin?
MediHelp rates the interaction as moderate. Bortezomib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to cytotoxic chemotherapy may stimulate proliferation of epithelial cells and increase the severity and duration of mucositis. Bortezomib is an antineoplastic agent, so the same timing caution applies. Palifermin has not been established for use with bortezomib.
How serious is the interaction between Bortezomib and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during or within 24 hours after bortezomib. Monitor for oral mucositis.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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