Drug interactions
Bortezomib + Ponesimod
Severity: Moderate
Bortezomib and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents reduce immune function, so using them together may increase the risk of serious infections. The effect on immunity from ponesimod can persist for some time after it is stopped.
What this interaction means in plain words
Bortezomib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Ponesimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from proteasome inhibition-related myelosuppression and sphingosine-1-phosphate receptor modulation reducing lymphocyte counts.
What to do
Monitor for signs of infection and check blood counts including lymphocytes regularly. Consider the persistence of ponesimod effects when sequencing therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Bortezomib with Ponesimod?
MediHelp rates the interaction as moderate. Bortezomib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents reduce immune function, so using them together may increase the risk of serious infections. The effect on immunity from ponesimod can persist for some time after it is stopped.
How serious is the interaction between Bortezomib and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts including lymphocytes regularly. Consider the persistence of ponesimod effects when sequencing therapies.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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