Drug interactions
Bortezomib + Siponimod
Severity: Moderate
Bortezomib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib commonly causes thrombocytopenia and neutropenia and increases herpes zoster reactivation, and siponimod lowers circulating lymphocytes. Together they can raise the risk of significant infection.
What this interaction means in plain words
Bortezomib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from proteasome inhibition effects on immune and bone marrow cells and S1P mediated lymphocyte sequestration.
What to do
Monitor CBC and infection signs, and give antiviral prophylaxis for herpes zoster as per bortezomib practice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Siponimod?
MediHelp rates the interaction as moderate. Bortezomib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib commonly causes thrombocytopenia and neutropenia and increases herpes zoster reactivation, and siponimod lowers circulating lymphocytes. Together they can raise the risk of significant infection.
How serious is the interaction between Bortezomib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CBC and infection signs, and give antiviral prophylaxis for herpes zoster as per bortezomib practice.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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