Drug interactions
Bosentan + Cabazitaxel
Severity: Moderate
Bosentan and Cabazitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower cabazitaxel exposure, reducing efficacy. Labeling advises avoiding strong CYP3A inducers, and bosentan has less potent induction.
What this interaction means in plain words
Bosentan and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Cabazitaxel belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing cabazitaxel metabolism.
What to do
Monitor treatment response; consider an alternative to bosentan if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Cabazitaxel?
MediHelp rates the interaction as moderate. Bosentan and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower cabazitaxel exposure, reducing efficacy. Labeling advises avoiding strong CYP3A inducers, and bosentan has less potent induction.
How serious is the interaction between Bosentan and Cabazitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response; consider an alternative to bosentan if feasible.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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