Drug interactions
Bosentan + Capivasertib
Severity: Moderate
Bosentan and Capivasertib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moderate CYP3A inducers such as bosentan lower capivasertib exposure. This may reduce its effectiveness in breast cancer treatment.
What this interaction means in plain words
Bosentan and Capivasertib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Capivasertib belongs to Oncology.
Why it happens
CYP3A4 induction by bosentan accelerates capivasertib metabolism.
What to do
Avoid concurrent use where an alternative to bosentan exists. If it cannot be avoided, monitor for reduced disease control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Bosentan with Capivasertib?
MediHelp rates the interaction as moderate. Bosentan and Capivasertib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moderate CYP3A inducers such as bosentan lower capivasertib exposure. This may reduce its effectiveness in breast cancer treatment.
How serious is the interaction between Bosentan and Capivasertib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative to bosentan exists. If it cannot be avoided, monitor for reduced disease control.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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