Drug interactions
Bosentan + Clopidogrel
Severity: Minor
Bosentan and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9 and possibly CYP2C19, which could increase formation of clopidogrel's active metabolite. The result may be modestly enhanced platelet inhibition, with unclear clinical importance.
What this interaction means in plain words
Bosentan and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Clopidogrel belongs to Cardiovascular.
Why it happens
Enzyme induction by bosentan may increase bioactivation of clopidogrel.
What to do
No dose change is generally needed; monitor for bleeding in patients on both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Clopidogrel?
MediHelp rates the interaction as minor. Bosentan and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and CYP2C9 and possibly CYP2C19, which could increase formation of clopidogrel's active metabolite. The result may be modestly enhanced platelet inhibition, with unclear clinical importance.
How serious is the interaction between Bosentan and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for bleeding in patients on both drugs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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