Drug interactions
Bosentan + Diclofenac
Severity: Minor
Bosentan and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP2C9 and CYP3A4 and may modestly reduce diclofenac exposure. Clinical consequence is probably limited to a reduced analgesic effect.
What this interaction means in plain words
Bosentan and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Diclofenac belongs to Musculoskeletal.
Why it happens
Induction of CYP2C9 by bosentan accelerates diclofenac metabolism.
What to do
No routine action is needed; assess pain control and adjust the diclofenac dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Diclofenac?
MediHelp rates the interaction as minor. Bosentan and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP2C9 and CYP3A4 and may modestly reduce diclofenac exposure. Clinical consequence is probably limited to a reduced analgesic effect.
How serious is the interaction between Bosentan and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; assess pain control and adjust the diclofenac dose if the response is inadequate.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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