Drug interactions
Bosentan + Dutasteride-tamsulosin
Severity: Moderate
Bosentan and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower tamsulosin and dutasteride concentrations. This could reduce the effect on urinary symptoms and prostate size. The effect is expected to be modest.
What this interaction means in plain words
Bosentan and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Bosentan induces CYP3A4 (and CYP2C9), increasing metabolism of tamsulosin and dutasteride.
What to do
Monitor urinary symptom control and consider adjusting therapy if response is lost. Also watch for additive hypotension from bosentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Bosentan and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower tamsulosin and dutasteride concentrations. This could reduce the effect on urinary symptoms and prostate size. The effect is expected to be modest.
How serious is the interaction between Bosentan and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and consider adjusting therapy if response is lost. Also watch for additive hypotension from bosentan.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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