Drug interactions
Bosentan + Eszopiclone
Severity: Minor
Bosentan and Eszopiclone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP3A4 inducer and may lower eszopiclone concentrations, since eszopiclone is cleared substantially by CYP3A4. The result could be a weaker or shorter hypnotic effect.
What this interaction means in plain words
Bosentan and Eszopiclone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Eszopiclone belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing the metabolic clearance of eszopiclone.
What to do
Monitor for reduced hypnotic efficacy and adjust eszopiclone dose within labeled limits if insomnia persists. Consider an alternative hypnotic not dependent on CYP3A4 if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eszopiclone
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Eszopiclone?
MediHelp rates the interaction as minor. Bosentan and Eszopiclone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a CYP3A4 inducer and may lower eszopiclone concentrations, since eszopiclone is cleared substantially by CYP3A4. The result could be a weaker or shorter hypnotic effect.
How serious is the interaction between Bosentan and Eszopiclone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and adjust eszopiclone dose within labeled limits if insomnia persists. Consider an alternative hypnotic not dependent on CYP3A4 if the response is inadequate.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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