Drug interactions
Bosentan + Gefitinib
Severity: Moderate
Bosentan and Gefitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower gefitinib concentrations, potentially reducing antitumor efficacy.
What this interaction means in plain words
Bosentan and Gefitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Gefitinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing gefitinib metabolism.
What to do
Monitor tumor response; consider an alternative to bosentan, or raise the gefitinib dose per labeling guidance for inducers and return to the usual dose after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Gefitinib
Frequently asked questions
Can I take Bosentan with Gefitinib?
MediHelp rates the interaction as moderate. Bosentan and Gefitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower gefitinib concentrations, potentially reducing antitumor efficacy.
How serious is the interaction between Bosentan and Gefitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response; consider an alternative to bosentan, or raise the gefitinib dose per labeling guidance for inducers and return to the usual dose after the inducer is stopped.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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