Drug interactions
Bosentan + Lapatinib
Severity: Moderate
Bosentan and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may substantially reduce lapatinib concentrations. Lower exposure could compromise cancer treatment effectiveness.
What this interaction means in plain words
Bosentan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing lapatinib clearance.
What to do
Prefer an alternative to bosentan where possible. If unavoidable, lapatinib dose titration per labeling for CYP3A4 inducers should be considered with monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Lapatinib?
MediHelp rates the interaction as moderate. Bosentan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may substantially reduce lapatinib concentrations. Lower exposure could compromise cancer treatment effectiveness.
How serious is the interaction between Bosentan and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to bosentan where possible. If unavoidable, lapatinib dose titration per labeling for CYP3A4 inducers should be considered with monitoring.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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