Drug interactions
Bosentan + Leniolisib
Severity: Moderate
Bosentan and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3, which mediate hepatic uptake of bosentan, so bosentan exposure may increase with greater hepatotoxicity and hypotension risk. Bosentan may also lower leniolisib exposure via CYP3A4 induction.
What this interaction means in plain words
Bosentan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits OATP1B1/1B3 uptake of bosentan, and bosentan induces CYP3A4 metabolism of leniolisib.
What to do
Monitor liver enzymes and blood pressure, and assess clinical response to leniolisib. Consider alternatives if either effect becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Bosentan with Leniolisib?
MediHelp rates the interaction as moderate. Bosentan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3, which mediate hepatic uptake of bosentan, so bosentan exposure may increase with greater hepatotoxicity and hypotension risk. Bosentan may also lower leniolisib exposure via CYP3A4 induction.
How serious is the interaction between Bosentan and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood pressure, and assess clinical response to leniolisib. Consider alternatives if either effect becomes significant.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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