Drug interactions
Bosentan + Levodopa
Severity: Moderate
Bosentan and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both levodopa and bosentan can lower blood pressure, so combined use may cause additive hypotension or orthostatic symptoms. This is a pharmacodynamic effect, not a change in drug levels.
What this interaction means in plain words
Bosentan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of levodopa and the vasodilating endothelin antagonist bosentan.
What to do
Monitor standing and sitting blood pressure, particularly at initiation or dose changes, and counsel on dizziness and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Bosentan with Levodopa?
MediHelp rates the interaction as moderate. Bosentan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both levodopa and bosentan can lower blood pressure, so combined use may cause additive hypotension or orthostatic symptoms. This is a pharmacodynamic effect, not a change in drug levels.
How serious is the interaction between Bosentan and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure, particularly at initiation or dose changes, and counsel on dizziness and falls.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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