Drug interactions
Bosentan + Lurbinectedin
Severity: Moderate
Bosentan and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower lurbinectedin exposure and reduce its anticancer efficacy. Labeling advises avoiding strong CYP3A inducers, and moderate inducers carry a lesser effect.
What this interaction means in plain words
Bosentan and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Lurbinectedin belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, the main enzyme metabolizing lurbinectedin.
What to do
Monitor tumor response and consider an alternative to bosentan if clinically possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Bosentan with Lurbinectedin?
MediHelp rates the interaction as moderate. Bosentan and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower lurbinectedin exposure and reduce its anticancer efficacy. Labeling advises avoiding strong CYP3A inducers, and moderate inducers carry a lesser effect.
How serious is the interaction between Bosentan and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider an alternative to bosentan if clinically possible.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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