Drug interactions
Bosentan + Naldemedine
Severity: Minor
Bosentan and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is metabolised by CYP3A4, and moderate inducers may reduce its exposure. The clinical effect is unknown, but the laxative effect could be reduced.
What this interaction means in plain words
Bosentan and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Bosentan induces CYP3A4, which may increase naldemedine clearance.
What to do
Monitor bowel function and watch for reduced response to naldemedine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Bosentan with Naldemedine?
MediHelp rates the interaction as minor. Bosentan and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is metabolised by CYP3A4, and moderate inducers may reduce its exposure. The clinical effect is unknown, but the laxative effect could be reduced.
How serious is the interaction between Bosentan and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and watch for reduced response to naldemedine.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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