Drug interactions
Bosentan + Nicardipine
Severity: Moderate
Bosentan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and can reduce nicardipine exposure, potentially weakening its antihypertensive effect.
What this interaction means in plain words
Bosentan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Bosentan induces CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure and titrate nicardipine upward if needed. Note that bosentan itself lowers blood pressure, so reassess if either drug is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Nicardipine?
MediHelp rates the interaction as moderate. Bosentan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and can reduce nicardipine exposure, potentially weakening its antihypertensive effect.
How serious is the interaction between Bosentan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine upward if needed. Note that bosentan itself lowers blood pressure, so reassess if either drug is changed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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