Drug interactions
Bosentan + Paclitaxel
Severity: Minor
Bosentan and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is an inducer of CYP3A4 and CYP2C9, and paclitaxel is partly metabolized by CYP3A4 and CYP2C8. Paclitaxel exposure could be modestly reduced, potentially lowering antitumor effect. No clinical data show a meaningful effect.
What this interaction means in plain words
Bosentan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
Bosentan may induce CYP3A4-mediated metabolism of paclitaxel, increasing its clearance.
What to do
No routine adjustment is needed; monitor treatment response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Paclitaxel?
MediHelp rates the interaction as minor. Bosentan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is an inducer of CYP3A4 and CYP2C9, and paclitaxel is partly metabolized by CYP3A4 and CYP2C8. Paclitaxel exposure could be modestly reduced, potentially lowering antitumor effect. No clinical data show a meaningful effect.
How serious is the interaction between Bosentan and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor treatment response and tolerability.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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