Drug interactions
Bosentan + Pexidartinib
Severity: Major
Bosentan and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolized by CYP3A4, and inducers may reduce its exposure and effect. Both drugs are also hepatotoxic, so combined use adds liver risk.
What this interaction means in plain words
Bosentan and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Pexidartinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing pexidartinib clearance, and both drugs carry hepatotoxic potential.
What to do
Avoid concurrent use where possible. If used together, monitor liver tests and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Bosentan with Pexidartinib?
MediHelp rates the interaction as major. Bosentan and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is metabolized by CYP3A4, and inducers may reduce its exposure and effect. Both drugs are also hepatotoxic, so combined use adds liver risk.
How serious is the interaction between Bosentan and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If used together, monitor liver tests and clinical response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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