Drug interactions
Bosentan + Primaquine
Severity: Moderate
Bosentan and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower primaquine concentrations, which could reduce its antimalarial effectiveness. Bosentan is a moderate CYP3A4 inducer, but the actual clinical effect on primaquine is not well characterized.
What this interaction means in plain words
Bosentan and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Primaquine belongs to Anti Parasitic.
Why it happens
Bosentan induces CYP3A4, potentially increasing primaquine metabolism.
What to do
Monitor for treatment failure or relapse of malaria when these are used together. Consider alternative therapy if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Primaquine?
MediHelp rates the interaction as moderate. Bosentan and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower primaquine concentrations, which could reduce its antimalarial effectiveness. Bosentan is a moderate CYP3A4 inducer, but the actual clinical effect on primaquine is not well characterized.
How serious is the interaction between Bosentan and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure or relapse of malaria when these are used together. Consider alternative therapy if response is inadequate.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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