Drug interactions
Bosentan + Propafenone
Severity: Minor
Bosentan and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce propafenone exposure. This may lessen antiarrhythmic effect, though the effect is likely modest because CYP2D6 is the main pathway.
What this interaction means in plain words
Bosentan and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Bosentan induction of CYP3A4 increases propafenone clearance.
What to do
Monitor for loss of arrhythmia control and ECG changes after bosentan is started. Adjust propafenone dose if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Propafenone?
MediHelp rates the interaction as minor. Bosentan and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and may reduce propafenone exposure. This may lessen antiarrhythmic effect, though the effect is likely modest because CYP2D6 is the main pathway.
How serious is the interaction between Bosentan and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of arrhythmia control and ECG changes after bosentan is started. Adjust propafenone dose if efficacy falls.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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