Drug interactions
Bosentan + Sufentanil
Severity: Minor
Bosentan and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and could reduce sufentanil exposure, potentially weakening analgesia or anesthesia. The effect is expected to be modest and titration of sufentanil usually compensates.
What this interaction means in plain words
Bosentan and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Sufentanil belongs to Musculoskeletal.
Why it happens
Bosentan induces CYP3A4, increasing sufentanil metabolism.
What to do
Titrate sufentanil to clinical effect and monitor analgesia and respiratory status. No empirical dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Bosentan with Sufentanil?
MediHelp rates the interaction as minor. Bosentan and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and could reduce sufentanil exposure, potentially weakening analgesia or anesthesia. The effect is expected to be modest and titration of sufentanil usually compensates.
How serious is the interaction between Bosentan and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to clinical effect and monitor analgesia and respiratory status. No empirical dose change is required.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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