Drug interactions
Bosentan + Tamsulosin
Severity: Minor
Bosentan and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce tamsulosin concentrations, potentially diminishing its effect on urinary symptoms. Both drugs can lower blood pressure, but the induction effect is the main concern.
What this interaction means in plain words
Bosentan and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Tamsulosin belongs to Genitourinary.
Why it happens
Bosentan induction of CYP3A4 increases tamsulosin clearance.
What to do
Monitor urinary symptom control and blood pressure. Adjust tamsulosin if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Tamsulosin?
MediHelp rates the interaction as minor. Bosentan and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and may reduce tamsulosin concentrations, potentially diminishing its effect on urinary symptoms. Both drugs can lower blood pressure, but the induction effect is the main concern.
How serious is the interaction between Bosentan and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and blood pressure. Adjust tamsulosin if response is inadequate.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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