Drug interactions
Bosentan + Tinidazole
Severity: Minor
Bosentan and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate inducer of CYP3A4 and tinidazole is partly cleared by CYP3A4, so tinidazole exposure could be lowered. The clinical impact on treatment of infections is likely small and is predicted rather than well documented.
What this interaction means in plain words
Bosentan and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Tinidazole belongs to Anti Parasitic.
Why it happens
Bosentan induction of CYP3A4 may increase the metabolic clearance of tinidazole.
What to do
No dose change is usually needed for standard courses; watch for lack of clinical response to tinidazole in difficult infections.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Tinidazole?
MediHelp rates the interaction as minor. Bosentan and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate inducer of CYP3A4 and tinidazole is partly cleared by CYP3A4, so tinidazole exposure could be lowered. The clinical impact on treatment of infections is likely small and is predicted rather than well documented.
How serious is the interaction between Bosentan and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for standard courses; watch for lack of clinical response to tinidazole in difficult infections.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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