Drug interactions
Bosentan + Voclosporin
Severity: Major
Bosentan and Voclosporin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower voclosporin concentrations, possibly reducing efficacy in lupus nephritis and raising the risk of flare.
What this interaction means in plain words
Bosentan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing voclosporin clearance.
What to do
Avoid moderate and strong CYP3A inducers with voclosporin where possible. If combined, monitor renal function and proteinuria and watch for lupus nephritis flare.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Bosentan with Voclosporin?
MediHelp rates the interaction as major. Bosentan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan may lower voclosporin concentrations, possibly reducing efficacy in lupus nephritis and raising the risk of flare.
How serious is the interaction between Bosentan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate and strong CYP3A inducers with voclosporin where possible. If combined, monitor renal function and proteinuria and watch for lupus nephritis flare.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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