Drug interactions
Bosutinib + Calcium
Severity: Moderate
Bosutinib and Calcium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib solubility falls as pH rises, so calcium carbonate antacids may reduce its absorption and exposure. This could weaken efficacy in leukemia treatment.
What this interaction means in plain words
Bosutinib and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Calcium belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH decreases the pH-dependent dissolution of bosutinib.
What to do
If an antacid is needed, use a short-acting one and separate it from bosutinib by at least 2 hours; avoid proton pump inhibitors where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Calcium?
MediHelp rates the interaction as moderate. Bosutinib and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib solubility falls as pH rises, so calcium carbonate antacids may reduce its absorption and exposure. This could weaken efficacy in leukemia treatment.
How serious is the interaction between Bosutinib and Calcium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, use a short-acting one and separate it from bosutinib by at least 2 hours; avoid proton pump inhibitors where possible.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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