Drug interactions
Bosutinib + Cimetidine
Severity: Moderate
Bosutinib and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib is a CYP3A4 substrate, and cimetidine may modestly raise its levels. Higher exposure could worsen gastrointestinal, hepatic and myelosuppressive toxicity. Cimetidine also reduces bosutinib solubility by raising gastric pH, which could offset this.
What this interaction means in plain words
Bosutinib and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by cimetidine may increase bosutinib exposure, while raised gastric pH may reduce absorption.
What to do
Monitor liver enzymes and for adverse effects, and consider a short-acting antacid separated from bosutinib instead of cimetidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Cimetidine?
MediHelp rates the interaction as moderate. Bosutinib and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib is a CYP3A4 substrate, and cimetidine may modestly raise its levels. Higher exposure could worsen gastrointestinal, hepatic and myelosuppressive toxicity. Cimetidine also reduces bosutinib solubility by raising gastric pH, which could offset this.
How serious is the interaction between Bosutinib and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for adverse effects, and consider a short-acting antacid separated from bosutinib instead of cimetidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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