Drug interactions
Bosutinib + Ciprofloxacin
Severity: Moderate
Bosutinib and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib may inhibit P-glycoprotein and slightly raise ciprofloxacin levels. Bosutinib can also prolong the QT interval, which is additive with ciprofloxacin.
What this interaction means in plain words
Bosutinib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by bosutinib, plus additive QT prolongation.
What to do
Monitor ECG and correct potassium and magnesium in patients with QT risk factors. Watch for ciprofloxacin adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Ciprofloxacin?
MediHelp rates the interaction as moderate. Bosutinib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib may inhibit P-glycoprotein and slightly raise ciprofloxacin levels. Bosutinib can also prolong the QT interval, which is additive with ciprofloxacin.
How serious is the interaction between Bosutinib and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium in patients with QT risk factors. Watch for ciprofloxacin adverse effects.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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