Drug interactions
Bosutinib + Desipramine
Severity: Moderate
Bosutinib and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib is metabolised mainly by CYP3A4, and desipramine is not a recognised clinically meaningful CYP3A4 inhibitor. Both drugs can prolong the QT interval, so combined use may add to arrhythmia risk, but the CYP3A4 mechanism described is not well supported.
What this interaction means in plain words
Bosutinib and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Desipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation is plausible; desipramine is not a significant CYP3A4 inhibitor, so a pharmacokinetic effect on bosutinib is not established.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG during treatment and consider an alternative antidepressant if the QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Desipramine?
MediHelp rates the interaction as moderate. Bosutinib and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib is metabolised mainly by CYP3A4, and desipramine is not a recognised clinically meaningful CYP3A4 inhibitor. Both drugs can prolong the QT interval, so combined use may add to arrhythmia risk, but the CYP3A4 mechanism described is not well supported.
How serious is the interaction between Bosutinib and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG during treatment and consider an alternative antidepressant if the QTc lengthens significantly.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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