Drug interactions
Bosutinib + Dexlansoprazole
Severity: Moderate
Bosutinib and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib absorption depends on gastric acidity, and proton pump inhibitors can reduce its exposure. This may compromise its efficacy in leukemia.
What this interaction means in plain words
Bosutinib and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces bosutinib solubility and absorption.
What to do
Avoid the PPI if possible, or use a short-acting antacid or H2 blocker separated from bosutinib. Monitor hematologic and molecular response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Dexlansoprazole?
MediHelp rates the interaction as moderate. Bosutinib and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib absorption depends on gastric acidity, and proton pump inhibitors can reduce its exposure. This may compromise its efficacy in leukemia.
How serious is the interaction between Bosutinib and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the PPI if possible, or use a short-acting antacid or H2 blocker separated from bosutinib. Monitor hematologic and molecular response.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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