Drug interactions
Bosutinib + Doxycycline
Severity: Minor
Bosutinib and Doxycycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxycycline might slightly raise bosutinib exposure through CYP3A4 inhibition, but this effect is weak and poorly documented. Bosutinib toxicity (diarrhea, hepatotoxicity, myelosuppression) could theoretically be increased.
What this interaction means in plain words
Bosutinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Doxycycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of CYP3A4-mediated bosutinib metabolism, not well established for doxycycline.
What to do
Continue both drugs if needed and monitor liver enzymes and blood counts as for routine bosutinib therapy. Report severe diarrhea or GI symptoms promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Doxycycline?
MediHelp rates the interaction as minor. Bosutinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxycycline might slightly raise bosutinib exposure through CYP3A4 inhibition, but this effect is weak and poorly documented. Bosutinib toxicity (diarrhea, hepatotoxicity, myelosuppression) could theoretically be increased.
How serious is the interaction between Bosutinib and Doxycycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue both drugs if needed and monitor liver enzymes and blood counts as for routine bosutinib therapy. Report severe diarrhea or GI symptoms promptly.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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