Drug interactions
Bosutinib + Famotidine
Severity: Moderate
Bosutinib and Famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib dissolves best in an acidic environment, and famotidine raises gastric pH. This can lower bosutinib absorption and exposure, potentially reducing its effect against leukemia.
What this interaction means in plain words
Bosutinib and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces pH-dependent solubility and absorption of bosutinib.
What to do
Avoid the combination if possible; if an acid reducer is needed, consider a short-acting antacid separated from bosutinib by at least 2 hours. Monitor disease response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Famotidine?
MediHelp rates the interaction as moderate. Bosutinib and Famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib dissolves best in an acidic environment, and famotidine raises gastric pH. This can lower bosutinib absorption and exposure, potentially reducing its effect against leukemia.
How serious is the interaction between Bosutinib and Famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if an acid reducer is needed, consider a short-acting antacid separated from bosutinib by at least 2 hours. Monitor disease response.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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