Drug interactions
Bosutinib + Nadolol
Severity: Minor
Bosutinib and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein and may increase nadolol exposure, with a risk of bradycardia and hypotension. The effect is predicted rather than well characterized.
What this interaction means in plain words
Bosutinib and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Nadolol belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by bosutinib increases nadolol absorption and reduces efflux.
What to do
Monitor heart rate and blood pressure after starting bosutinib and lower the nadolol dose if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Nadolol?
MediHelp rates the interaction as minor. Bosutinib and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib inhibits P-glycoprotein and may increase nadolol exposure, with a risk of bradycardia and hypotension. The effect is predicted rather than well characterized.
How serious is the interaction between Bosutinib and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting bosutinib and lower the nadolol dose if symptomatic bradycardia occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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