Drug interactions
Bosutinib + Nicardipine
Severity: Moderate
Bosutinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations. This could increase gastrointestinal, hepatic and myelosuppressive toxicity.
What this interaction means in plain words
Bosutinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux of bosutinib by nicardipine.
What to do
Monitor liver enzymes, blood counts and gastrointestinal tolerability, and reduce the bosutinib dose if toxicity develops. Choose an alternative antihypertensive if effects are significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Nicardipine?
MediHelp rates the interaction as moderate. Bosutinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations. This could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, blood counts and gastrointestinal tolerability, and reduce the bosutinib dose if toxicity develops. Choose an alternative antihypertensive if effects are significant.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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