Drug interactions
Bosutinib + Paclitaxel
Severity: Moderate
Bosutinib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein and may increase paclitaxel exposure. Both drugs can also cause myelosuppression, so toxicity may be additive.
What this interaction means in plain words
Bosutinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
P-gp inhibition by bosutinib reduces paclitaxel efflux, plus additive myelosuppression.
What to do
Monitor blood counts and neuropathy regularly. Adjust the paclitaxel dose if neutropenia or neurotoxicity worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Paclitaxel?
MediHelp rates the interaction as moderate. Bosutinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein and may increase paclitaxel exposure. Both drugs can also cause myelosuppression, so toxicity may be additive.
How serious is the interaction between Bosutinib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy regularly. Adjust the paclitaxel dose if neutropenia or neurotoxicity worsens.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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