Drug interactions
Bosutinib + Propafenone
Severity: Moderate
Bosutinib and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-glycoprotein and may increase bosutinib exposure, raising the risk of gastrointestinal, hepatic and other toxicities. The magnitude of effect is uncertain.
What this interaction means in plain words
Bosutinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibits P-glycoprotein efflux of bosutinib, increasing its absorption and exposure.
What to do
Monitor for bosutinib adverse effects such as diarrhea and liver enzyme elevation, and reduce the dose if toxicity occurs. Consider an alternative antiarrhythmic if toxicity is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Propafenone?
MediHelp rates the interaction as moderate. Bosutinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits P-glycoprotein and may increase bosutinib exposure, raising the risk of gastrointestinal, hepatic and other toxicities. The magnitude of effect is uncertain.
How serious is the interaction between Bosutinib and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bosutinib adverse effects such as diarrhea and liver enzyme elevation, and reduce the dose if toxicity occurs. Consider an alternative antiarrhythmic if toxicity is troublesome.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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