Drug interactions
Bosutinib + Quinidine
Severity: Major
Bosutinib and Quinidine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may increase bosutinib exposure, raising the risk of gastrointestinal, hepatic and myelosuppressive toxicity. Bosutinib can also have QT effects, adding to quinidine's.
What this interaction means in plain words
Bosutinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein and CYP3A4, decreasing bosutinib efflux and metabolism.
What to do
Prefer an alternative antiarrhythmic. If combined, monitor for bosutinib toxicity and ECG, and consider reducing the bosutinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Quinidine?
MediHelp rates the interaction as major. Bosutinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine may increase bosutinib exposure, raising the risk of gastrointestinal, hepatic and myelosuppressive toxicity. Bosutinib can also have QT effects, adding to quinidine's.
How serious is the interaction between Bosutinib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiarrhythmic. If combined, monitor for bosutinib toxicity and ECG, and consider reducing the bosutinib dose.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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