Drug interactions
Bosutinib + Sertraline
Severity: Minor
Bosutinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib is a CYP3A4 substrate, and sertraline is a weak inhibitor, so the rise in bosutinib exposure is likely small. Bosutinib toxicity such as diarrhea, liver enzyme elevation and myelosuppression could become more frequent.
What this interaction means in plain words
Bosutinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may modestly reduce bosutinib clearance.
What to do
No routine dose change is needed. Monitor liver enzymes, blood counts and gastrointestinal tolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Sertraline?
MediHelp rates the interaction as minor. Bosutinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib is a CYP3A4 substrate, and sertraline is a weak inhibitor, so the rise in bosutinib exposure is likely small. Bosutinib toxicity such as diarrhea, liver enzyme elevation and myelosuppression could become more frequent.
How serious is the interaction between Bosutinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor liver enzymes, blood counts and gastrointestinal tolerance.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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