Drug interactions
Bremelanotide + Cyclosporine
Severity: Moderate
Bremelanotide and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may slow gastric emptying and reduce the rate and extent of absorption of oral drugs. Cyclosporine has a narrow therapeutic index, so reduced absorption could lead to subtherapeutic levels and risk of graft rejection.
What this interaction means in plain words
Bremelanotide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Delayed gastric emptying from bremelanotide may reduce oral absorption of cyclosporine.
What to do
Monitor cyclosporine trough concentrations if bremelanotide is used, and adjust the dose as needed. Limit bremelanotide to occasional use per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
- Bremelanotide + Tacrolimus Moderate
Frequently asked questions
Can I take Bremelanotide with Cyclosporine?
MediHelp rates the interaction as moderate. Bremelanotide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bremelanotide may slow gastric emptying and reduce the rate and extent of absorption of oral drugs. Cyclosporine has a narrow therapeutic index, so reduced absorption could lead to subtherapeutic levels and risk of graft rejection.
How serious is the interaction between Bremelanotide and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations if bremelanotide is used, and adjust the dose as needed. Limit bremelanotide to occasional use per labeling.
What other medicines interact with Bremelanotide?
MediHelp also lists interactions of Bremelanotide with, for example, Bupropion-naltrexone, Digoxin, Disopyramide. The full list is on the Bremelanotide page.
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