Drug interactions
Bremelanotide + Tacrolimus
Severity: Moderate
Bremelanotide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may slow gastric emptying and could theoretically reduce the rate or extent of absorption of oral tacrolimus. Because tacrolimus has a narrow therapeutic range, lower exposure could risk under-immunosuppression.
What this interaction means in plain words
Bremelanotide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bremelanotide belongs to Genitourinary; Tacrolimus belongs to Miscellaneous.
Why it happens
Delayed gastric emptying with bremelanotide may reduce oral absorption of tacrolimus.
What to do
Monitor tacrolimus trough concentrations after bremelanotide is started, and adjust the tacrolimus dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporine Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Tacrolimus?
MediHelp rates the interaction as moderate. Bremelanotide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bremelanotide may slow gastric emptying and could theoretically reduce the rate or extent of absorption of oral tacrolimus. Because tacrolimus has a narrow therapeutic range, lower exposure could risk under-immunosuppression.
How serious is the interaction between Bremelanotide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations after bremelanotide is started, and adjust the tacrolimus dose according to levels.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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