Drug interactions
Bremelanotide + Methadone
Severity: Minor
Bremelanotide and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs. This could theoretically lower or delay methadone absorption, but the effect on methadone has not been well characterized and is likely small with intermittent use.
What this interaction means in plain words
Bremelanotide and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bremelanotide belongs to Genitourinary; Methadone belongs to Musculoskeletal.
Why it happens
Delayed gastric emptying by bremelanotide may reduce oral absorption of methadone.
What to do
No routine change is needed; monitor for signs of withdrawal or reduced effect if methadone is taken near the time of bremelanotide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bremelanotide and Methadone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Methadone?
MediHelp rates the interaction as minor. Bremelanotide and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide slows gastric emptying and may reduce the rate and extent of absorption of oral drugs. This could theoretically lower or delay methadone absorption, but the effect on methadone has not been well characterized and is likely small with intermittent use.
How serious is the interaction between Bremelanotide and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for signs of withdrawal or reduced effect if methadone is taken near the time of bremelanotide.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
