Drug interactions
Brentuximab + Cobicistat
Severity: Moderate
Brentuximab and Cobicistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and also inhibits P-gp, which may raise exposure to MMAE from brentuximab vedotin. This increases the risk of neutropenia and peripheral neuropathy.
What this interaction means in plain words
Brentuximab and Cobicistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Cobicistat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 and P-gp reduces MMAE metabolism and efflux.
What to do
Monitor blood counts and neuropathy closely, and consider an alternative regimen if toxicity develops. Delay or reduce brentuximab doses for neutropenia per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Brentuximab with Cobicistat?
MediHelp rates the interaction as moderate. Brentuximab and Cobicistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and also inhibits P-gp, which may raise exposure to MMAE from brentuximab vedotin. This increases the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab and Cobicistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely, and consider an alternative regimen if toxicity develops. Delay or reduce brentuximab doses for neutropenia per labeling.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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