Drug interactions
Brentuximab + Imatinib
Severity: Moderate
Brentuximab and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase MMAE exposure from brentuximab vedotin. Both drugs can cause myelosuppression, so toxicity may be greater.
What this interaction means in plain words
Brentuximab and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Moderate CYP3A4 inhibition reduces MMAE clearance, with additive myelosuppression.
What to do
Monitor blood counts and for neuropathy or infection during combined use; delay or reduce treatment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Brentuximab with Imatinib?
MediHelp rates the interaction as moderate. Brentuximab and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may increase MMAE exposure from brentuximab vedotin. Both drugs can cause myelosuppression, so toxicity may be greater.
How serious is the interaction between Brentuximab and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy or infection during combined use; delay or reduce treatment if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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