Drug interactions
Brentuximab + Lenacapavir
Severity: Moderate
Brentuximab and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may raise exposure to MMAE released from brentuximab vedotin. This could increase MMAE-related toxicities such as neutropenia and neuropathy, and the effect may persist for months after the last injection.
What this interaction means in plain words
Brentuximab and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated MMAE metabolism.
What to do
Monitor for neutropenia and peripheral neuropathy and consider delaying doses or reducing them if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Brentuximab with Lenacapavir?
MediHelp rates the interaction as moderate. Brentuximab and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may raise exposure to MMAE released from brentuximab vedotin. This could increase MMAE-related toxicities such as neutropenia and neuropathy, and the effect may persist for months after the last injection.
How serious is the interaction between Brentuximab and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neutropenia and peripheral neuropathy and consider delaying doses or reducing them if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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