Drug interactions
Brentuximab + Voxelotor
Severity: Moderate
Brentuximab and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 in vitro and raises exposure of sensitive CYP3A4 substrates. MMAE from brentuximab vedotin is a CYP3A4 substrate, so it may accumulate and increase toxicity, although the effect is likely modest.
What this interaction means in plain words
Brentuximab and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by voxelotor may reduce MMAE clearance.
What to do
Monitor blood counts and neuropathy. Reduce or hold brentuximab vedotin if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Brentuximab with Voxelotor?
MediHelp rates the interaction as moderate. Brentuximab and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 in vitro and raises exposure of sensitive CYP3A4 substrates. MMAE from brentuximab vedotin is a CYP3A4 substrate, so it may accumulate and increase toxicity, although the effect is likely modest.
How serious is the interaction between Brentuximab and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy. Reduce or hold brentuximab vedotin if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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