Drug interactions
Brentuximab vedotin + Nicardipine
Severity: Minor
Brentuximab vedotin and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab's cytotoxic component MMAE is metabolised by CYP3A4, so inhibitors can raise its exposure. Nicardipine is only a weak inhibitor, so the effect is likely small, but increased neutropenia or neuropathy is possible.
What this interaction means in plain words
Brentuximab vedotin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab vedotin belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nicardipine may increase free MMAE exposure.
What to do
Monitor blood counts and for peripheral neuropathy. No pre-emptive dose change is generally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Nicardipine?
MediHelp rates the interaction as minor. Brentuximab vedotin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brentuximab's cytotoxic component MMAE is metabolised by CYP3A4, so inhibitors can raise its exposure. Nicardipine is only a weak inhibitor, so the effect is likely small, but increased neutropenia or neuropathy is possible.
How serious is the interaction between Brentuximab vedotin and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for peripheral neuropathy. No pre-emptive dose change is generally required.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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