Drug interactions
Brentuximab vedotin + Rifampicin
Severity: Moderate
Brentuximab vedotin and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers exposure to MMAE, the cytotoxic component released from brentuximab vedotin. This may reduce antitumor efficacy.
What this interaction means in plain words
Brentuximab vedotin and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces CYP3A4, increasing MMAE metabolism.
What to do
Where possible, choose an alternative to rifampicin. If it must be used, monitor for reduced tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Brentuximab vedotin with Rifampicin?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin lowers exposure to MMAE, the cytotoxic component released from brentuximab vedotin. This may reduce antitumor efficacy.
How serious is the interaction between Brentuximab vedotin and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, choose an alternative to rifampicin. If it must be used, monitor for reduced tumor response.
What other medicines interact with Brentuximab vedotin?
MediHelp also lists interactions of Brentuximab vedotin with, for example, Bleomycin, Siponimod, Apalutamide. The full list is on the Brentuximab vedotin page.
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