Drug interactions
Bretylium + Bumetanide
Severity: Moderate
Bretylium and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension through adrenergic neuron blockade, and bumetanide-induced volume depletion may worsen it. The combination can lead to significant orthostatic or sustained hypotension.
What this interaction means in plain words
Bretylium and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from adrenergic neuron blockade and diuretic-induced volume depletion.
What to do
Correct volume depletion before bretylium and monitor blood pressure closely. Reduce the bumetanide dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Frequently asked questions
Can I take Bretylium with Bumetanide?
MediHelp rates the interaction as moderate. Bretylium and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension through adrenergic neuron blockade, and bumetanide-induced volume depletion may worsen it. The combination can lead to significant orthostatic or sustained hypotension.
How serious is the interaction between Bretylium and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct volume depletion before bretylium and monitor blood pressure closely. Reduce the bumetanide dose if hypotension occurs.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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