Drug interactions
Bretylium + Hydrochlorothiazide-irbesartan
Severity: Moderate
Bretylium and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes orthostatic hypotension through adrenergic neuron blockade, and antihypertensives such as hydrochlorothiazide and irbesartan may worsen it. This can lead to symptomatic hypotension in patients with arrhythmias.
What this interaction means in plain words
Bretylium and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade, diuresis and angiotensin receptor blockade.
What to do
Monitor blood pressure closely, keep the patient supine during bretylium administration, and reduce or hold antihypertensives if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Bretylium with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Bretylium and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes orthostatic hypotension through adrenergic neuron blockade, and antihypertensives such as hydrochlorothiazide and irbesartan may worsen it. This can lead to symptomatic hypotension in patients with arrhythmias.
How serious is the interaction between Bretylium and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, keep the patient supine during bretylium administration, and reduce or hold antihypertensives if hypotension develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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