Drug interactions
Bretylium + Sotalol
Severity: Moderate
Bretylium and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause hypotension, and bretylium also has complex effects on the QT interval and arrhythmias. Combined use may cause marked hypotension or proarrhythmia.
What this interaction means in plain words
Bretylium and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and antiarrhythmic effects, with adrenergic neuron blockade from bretylium.
What to do
Monitor blood pressure and ECG continuously when used together, and manage hypotension with fluids or support as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Bretylium with Sotalol?
MediHelp rates the interaction as moderate. Bretylium and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause hypotension, and bretylium also has complex effects on the QT interval and arrhythmias. Combined use may cause marked hypotension or proarrhythmia.
How serious is the interaction between Bretylium and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG continuously when used together, and manage hypotension with fluids or support as required.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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