Drug interactions
Brexanolone + Dantrolene
Severity: Moderate
Brexanolone and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and dantrolene adds to drowsiness. Combined use may intensify sedation.
What this interaction means in plain words
Brexanolone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects via GABA-A modulation and dantrolene sedation.
What to do
Monitor sedation level and pulse oximetry during the brexanolone infusion as per labeling. Reduce or interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Brexanolone with Dantrolene?
MediHelp rates the interaction as moderate. Brexanolone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness, and dantrolene adds to drowsiness. Combined use may intensify sedation.
How serious is the interaction between Brexanolone and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and pulse oximetry during the brexanolone infusion as per labeling. Reduce or interrupt the infusion if excessive sedation occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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